Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms
نویسندگان
چکیده
منابع مشابه
Electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-inflammatory mechanism
Introduction Ischemic strokes, caused by cerebral artery stenosis or occlusion, lead to a reduction or abrupt interruption of local cerebral blood flow, resulting in anoxia in the arterial territory, secondary vascular endothelial injury, and the initiation of various pathological conditions (Jian et al., 2013; Kim et al., 2013; Wang et al., 2014). With technological advances, the clinical diag...
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BACKGROUND AND PURPOSE Current available therapies for neonatal hypoxia/ischemia (H/I) brain injury are rather limited. Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H/I in neonates. METHODS Female rats were treated with or without an omega-3 polyunsaturated fatty acids-enriched diet from the second day of pre...
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Objective(s): This study was conducted to evaluate the cerebroprotective effect of methanolic leaf extract of Punica granatum (MePG) in Wistar rats.Materials and Methods: The MePG was initially assessed for in vitro antioxidant activity, and later evaluated on LPS-induced RAW 264.7 cell line assay. Finally, the MePG was evaluated against ischemia-reperfusion (I/R) induced brain injury in Wistar...
متن کاملEthyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
PURPOSE Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after regional I/R injury and whether ethyl pyruvate protects against delayed regional I/R injury in an in vivo rat heart model after a 24 hours reperfusion. MATERIAL...
متن کاملNAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation
Nicotinamide phosphoribosyltransferase (NAMPT) is an important neuroprotective factor in cerebral ischemia, and it has been reported that NAMPT inhibitors can aggravate neuronal injury in the acute phase. However, because it is a cytokine, NAMPT participates in many inflammatory diseases in the peripheral system, and its inhibitors have therapeutic effects. Following cerebral ischemia, the peri...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2010
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2009.12.010